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Episode Description
In this episode of Neural Compass, David Eagleman—Stanford neuroscientist, bestselling author of Livewired, and one of today’s leading communicators of brain science—joins Jimini’s Mark Jacobstein to explore the astonishing adaptability of the human brain and its implications for therapy, technology, and society.
This episode touches on:
- Why Eagleman calls the brain livewired—not “plastic”—and how it constantly reshapes itself
- How neuroplasticity is central to everything from therapy to psychedelics to brain stimulation
- The promise of sensory substitution—from helping deaf individuals “hear” through vibrations to new frontiers in brain–computer interfaces
- The legal and ethical questions raised when brain science meets crime, culpability, and justice
- The future of human–AI interaction—from companion robots to algorithms that could reduce polarization instead of fueling it
About Our Guest
David Eagleman is an American neuroscientist, bestselling author, and science communicator. He teaches neuroscience at Stanford University and has founded several neurotech startups. He directs the non-profit Center for Science and Law, which seeks to align the legal system with modern neuroscience. He is known for his work on brain plasticity, time perception, synesthesia, and neurolaw. He is a Guggenheim Fellow and a New York Times-bestselling author published in 32 languages. He is the writer and presenter of the international television series The Brain with David Eagleman and the host of the podcast Inner Cosmos with David Eagleman. His podcast has been ranked as the number-one science podcast on Apple several times and in 2024 was nominated for the best science podcast of the year at the iHeart Podcast Awards at SXSW.
About Our Host
Mark Jacobstein is the co-founder and president of Jimini Health. A longtime entrepreneur at the intersection of AI and health tech, he now leads Jimini’s mission to transform mental and behavioral health through clinically grounded, AI-powered care.

